Chemo Decisions and HER2

We go in for a final appointment before chemo to discuss just what we'll take and what the effects will be. Just as we're getting started we discover the path report from surgery #4 showed us as having a 2+ score on the ICH test for the HER2 receptor. Oh shit. Our first path report showed us as being HER2- and we rejoiced because HER2+ tumors have a worse prognosis.

This ends our dicussion of chemo treatments, we can't pick one until we know HER2 status. We go home and read that 2+ ICH score is ambiguous and they must do a "FISH" test to tell for sure. The next day we discover the FISH test was already done (but not not entered in the computer at Mayo) and we are indeed HER2 negative.

It sure made for a horrible night though.

We have a friend who is getting considerably more chemotherapy because she is HER2+. In all other respects we are almost the same (stage II, node negative, ER+, PR+, about 40 years old). We sure did not want to hear that was our future.

And it all delays us yet another week.

Needle biopsy

Today we had a needle biopsy. We thought this was a formality and would reveal another fibrocystic lump we'd have to remove. Not so and this is the beginning of a long road. Two days later our path report tells us we had two locations reveal cancer and DCIS, one at least 10mm, the other 12mm. We later learn there is only one tumor, but at this time we're scared there are two.

The good news is "low grade" and "low mitotic rate" and "lymphatic invasion is not seen", this means our tumor appears to be slow growing and mild. Also we're ER+ and PR+ which means estrogen receptors and progesterone receptors are on the cancer cells. That's good news because it means we can use hormone therapy to fight the cancer cells. Finally we're also HER2 negative, this is good because HER2+ is associated with more aggressive cancers.